Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells

BACKGROUND: Recent evidence suggests that the aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas, including colorectal cancer (CRC). Forkhead box M1 (FoxM1) controls the expression of a number of cell cycle regula...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Wang, DeJie, Hu, Guohui, Du, Ying, Zhang, Cheng, Lu, Quqin, Lv, Nonghua, Luo, Shiwen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288899/
https://ncbi.nlm.nih.gov/pubmed/28148279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0491-7
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