Assessment of Tryptophan Uptake and Kinetics Using 1-(2-(18)F-Fluoroethyl)-l-Tryptophan and α-(11)C-Methyl-l-Tryptophan PET Imaging in Mice Implanted with Patient-Derived Brain Tumor Xenografts

Abnormal tryptophan metabolism via the kynurenine pathway is involved in the pathophysiology of a variety of human diseases including cancers. α-(11)C-methyl-l-tryptophan ((11)C-AMT) PET imaging demonstrated increased tryptophan uptake and trapping in epileptic foci and brain tumors, but the short h...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Michelhaugh, Sharon K., Muzik, Otto, Guastella, Anthony R., Klinger, Neil V., Polin, Lisa A., Cai, Hancheng, Xin, Yangchun, Mangner, Thomas J., Zhang, Shaohui, Juhász, Csaba, Mittal, Sandeep
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2017
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288739/
https://ncbi.nlm.nih.gov/pubmed/27765857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.116.179994
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