Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage

Nitric oxide synthase 2, inducible (Nos2) expression is necessary for the microbicidal activity of macrophages. However, NOS2 over-activation causes multiple inflammatory disorders, suggesting a tight gene regulation is necessary. Using cytosolic flagellin as a model for inflammasome-dependent NOS2...

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Publicat a:Sci Rep
Autors principals: Buzzo, Carina de Lima, Medina, Tiago, Branco, Laura M., Lage, Silvia L., Ferreira, Luís Carlos de Souza, Amarante-Mendes, Gustavo P., Hottiger, Michael O., De Carvalho, Daniel D., Bortoluci, Karina R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288713/
https://ncbi.nlm.nih.gov/pubmed/28150715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41686
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