Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells

We recently reported that knockdown of delta-5-desaturase (a key enzyme that converts dihomo-γ-linolenic acid, DGLA, to the downstream ω-6 arachidonic acid) promotes formation of an anti-cancer byproduct 8-hydroxyoctanoic acid from cyclooxygenase (COX)-catalyzed DGLA peroxidation. 8-hydroxyoctanoic...

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Vydáno v:Redox Biol
Hlavní autoři: Yang, Xiaoyu, Xu, Yi, Wang, Tao, Shu, Dan, Guo, Peixuan, Miskimins, Keith, Qian, Steven Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288391/
https://ncbi.nlm.nih.gov/pubmed/28157665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.01.016
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