Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells

We recently reported that knockdown of delta-5-desaturase (a key enzyme that converts dihomo-γ-linolenic acid, DGLA, to the downstream ω-6 arachidonic acid) promotes formation of an anti-cancer byproduct 8-hydroxyoctanoic acid from cyclooxygenase (COX)-catalyzed DGLA peroxidation. 8-hydroxyoctanoic...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Redox Biol
Main Authors: Yang, Xiaoyu, Xu, Yi, Wang, Tao, Shu, Dan, Guo, Peixuan, Miskimins, Keith, Qian, Steven Y.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288391/
https://ncbi.nlm.nih.gov/pubmed/28157665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.01.016
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