Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression

We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn inhibits cancer cell growth and migration. However, delivery of naked siRNA remains a f...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Xu, Yi, Pang, Lizhi, Wang, Hongzhi, Xu, Congcong, Shah, Harshit, Guo, Peixuan, Shu, Dan, Qian, Steven Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305700/
https://ncbi.nlm.nih.gov/pubmed/30584980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.101085
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