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Detecting Rare and Common Haplotype–Environment Interaction under Uncertainty of Gene–Environment Independence Assumption
Finding rare variants and gene-environment interactions (GXE) are critical in dissecting complex diseases. We consider the problem of detecting GXE where G is a rare haplotype and E is a non-genetic factor. Such methods typically assume G-E independence, which may not hold in many applications. A pe...
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| Published in: | Biometrics |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5288316/ https://ncbi.nlm.nih.gov/pubmed/27478935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/biom.12567 |
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