Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma

Checkpoint kinase 1 (CHK1) is an integral component of the cell cycle as well as the DNA Damage Response (DDR) pathway. Previous work has demonstrated the effectiveness of inhibiting CHK1 with small-molecule inhibitors, but the role of CHK1 mediated DDR in medulloblastoma is unknown. CHK1, both at t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Prince, Eric W., Balakrishnan, Ilango, Shah, Monil, Mulcahy Levy, Jean M., Griesinger, Andrea M., Alimova, Irina, Harris, Peter S., Birks, Diane K., Donson, Andrew M., Davidson, Nathan, Remke, Marc, Taylor, Michael D., Handler, Michael H., Foreman, Nicholas K., Venkataraman, Sujatha, Vibhakar, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288228/
https://ncbi.nlm.nih.gov/pubmed/27449089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10692
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