Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma

Medulloblastoma is a pediatric brain tumor with a variable prognosis due to clinical and genomic heterogeneity. Among the 4 major genomic sub-groups, patients with MYC amplified tumors have a particularly poor prognosis despite therapy with surgery, radiation and chemotherapy. Targeting the MYC onco...

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Detalhes bibliográficos
Main Authors: Venkataraman, Sujatha, Alimova, Irina, Balakrishnan, Ilango, Harris, Peter, Birks, Diane K, Griesinger, Andrea, Amani, Vladimir, Cristiano, Brian, Remke, Marc, Taylor, Michael D, Handler, Michael, Foreman, Nicholas K, Vibhakar, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058011/
https://ncbi.nlm.nih.gov/pubmed/24796395
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