Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy

We have recently shown that caspase-8 is a new substrate of Polo-like kinase 3 (Plk3) that phosphorylates the protein on residue T273 thereby promoting its pro-apoptotic function. In the present study we aimed to investigate the clinical relevance of Plk3 expression and phosphorylation of caspase-8...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Rödel, Franz, Martin, Daniel, Helmke, Christina, Balermpas, Panagiotis, Fokas, Emmanouil, Wieland, Ulrike, Rave-Fränk, Margret, Kitz, Julia, Matthess, Yves, Raab, Monika, Strebhardt, Klaus, Rödel, Claus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288191/
https://ncbi.nlm.nih.gov/pubmed/27462786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10801
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