Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer

FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins for ubiquitination and degradation by the proteasome. FBXW7 regulates cellular apoptosis by targeting MCL1 for ubiquitination. Recently, we identified PLK1 as a new substrat...

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Foilsithe in:Oncotarget
Main Authors: Gasca, Jessica, Flores, Maria Luz, Giráldez, Servando, Ruiz-Borrego, Manuel, Tortolero, María, Romero, Francisco, Japón, Miguel A., Sáez, Carmen
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper: Pathology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288146/
https://ncbi.nlm.nih.gov/pubmed/27409838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10481
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