p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression

SV40 large T-antigen (T-ag) has been known for decades to inactivate the tumor suppressor p53 by sequestration and additional mechanisms. Our present study revealed that the struggle between p53 and T-ag begins very early in the infection cycle. We found that p53 is activated early after SV40 infect...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Drayman, Nir, Ben-nun-Shaul, Orly, Butin-Israeli, Veronika, Srivastava, Rohit, Rubinstein, Ariel M., Mock, Caroline S., Elyada, Ela, Ben-Neriah, Yinon, Lahav, Galit, Oppenheim, Ariella
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288138/
https://ncbi.nlm.nih.gov/pubmed/27462916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10769
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