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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Calorie restriction can extend life span in a variety of species including mammals, flies, nematodes, and yeast. Despite the importance of this nearly universal effect, little is understood about the molecular mechanisms that mediate the life-span-extending effect of calorie restriction in metazoans...

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Autori principali: Rogina, Blanka, Helfand, Stephen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC528752/
https://ncbi.nlm.nih.gov/pubmed/15520384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404184101
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