BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study

BACKGROUND: BK-UM (CRM197) is a mutant form of diphtheria toxin and a specific inhibitor of heparin-binding epidermal growth factor-like growth factor (HB-EGF). We assessed the safety, pharmacokinetics, recommended dose, and efficacy of BK-UM in patients with recurrent ovarian cancer (OC) or periton...

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Bibliografische gegevens
Gepubliceerd in:BMC Cancer
Hoofdauteurs: Miyamoto, Shingo, Yotsumoto, Fusanori, Ueda, Taeko, Fukami, Tatsuya, Sanui, Ayako, Miyata, Kohei, Nam, Sung Ouk, Fukagawa, Satoshi, Katsuta, Takahiro, Maehara, Miyako, Kondo, Haruhiko, Miyahara, Daisuke, Shirota, Kyoko, Yoshizato, Toshiyuki, Kuroki, Masahide, Nishikawa, Hiroaki, Saku, Keijiro, Tsuboi, Yoshio, Ishitsuka, Kenji, Takamatsu, Yasushi, Tamura, Kazuo, Matsunaga, Akira, Hachisuga, Toru, Nishino, Shinsuke, Odawara, Takashi, Maeda, Kazuhiro, Manabe, Sadao, Ishikawa, Toyokazu, Okuno, Yoshinobu, Ohishi, Minako, Hikita, Tomoya, Mizushima, Hiroto, Iwamoto, Ryo, Mekada, Eisuke
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286856/
https://ncbi.nlm.nih.gov/pubmed/28143428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3071-5
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