Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors

Ligand-gated ion channels enable intercellular transmission of action potential through synapses by transducing biochemical messengers into electrical signal. We designed artificial ligand-gated ion channels by coupling G protein-coupled receptors to the Kir6.2 potassium channel. These artificial ch...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Moreau, Christophe J., Revilloud, Jean, Caro, Lydia N., Dupuis, Julien P., Trouchet, Amandine, Estrada-Mondragón, Argel, Nieścierowicz, Katarzyna, Sapay, Nicolas, Crouzy, Serge, Vivaudou, Michel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286527/
https://ncbi.nlm.nih.gov/pubmed/28145461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41154
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