Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors

Ligand-gated ion channels enable intercellular transmission of action potential through synapses by transducing biochemical messengers into electrical signal. We designed artificial ligand-gated ion channels by coupling G protein-coupled receptors to the Kir6.2 potassium channel. These artificial ch...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Moreau, Christophe J., Revilloud, Jean, Caro, Lydia N., Dupuis, Julien P., Trouchet, Amandine, Estrada-Mondragón, Argel, Nieścierowicz, Katarzyna, Sapay, Nicolas, Crouzy, Serge, Vivaudou, Michel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286527/
https://ncbi.nlm.nih.gov/pubmed/28145461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41154
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi