Development of a human vasopressin V(1a)-receptor antagonist from an evolutionary-related insect neuropeptide

Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary con...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Di Giglio, Maria Giulia, Muttenthaler, Markus, Harpsøe, Kasper, Liutkeviciute, Zita, Keov, Peter, Eder, Thomas, Rattei, Thomas, Arrowsmith, Sarah, Wray, Susan, Marek, Ales, Elbert, Tomas, Alewood, Paul F., Gloriam, David E., Gruber, Christian W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286520/
https://ncbi.nlm.nih.gov/pubmed/28145450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41002
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