Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Vasopressin (VP) and oxytocin (OT) are cyclic neuropeptides that regulate fundamental physiological functions via four G protein-coupled receptors, V(1a)R, V(1b)R, V(2)R, and OTR. Ligand development remains challenging for these receptors due to complex structure–activity relationships. Here, we inv...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Dekan, Zoltan, Kremsmayr, Thomas, Keov, Peter, Godin, Mathilde, Teakle, Ngari, Dürrauer, Leopold, Xiang, Huang, Gharib, Dalia, Bergmayr, Christian, Hellinger, Roland, Gay, Marina, Vilaseca, Marta, Kurzbach, Dennis, Albericio, Fernando, Alewood, Paul F., Gruber, Christian W., Muttenthaler, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2021
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179488/
https://ncbi.nlm.nih.gov/pubmed/34163676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05501h
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados