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The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCF (FBXW7) function
The F‐box protein FBXW7 is the substrate‐recruiting subunit of an SCF ubiquitin ligase and a major tumor‐suppressor protein that is altered in several human malignancies. Loss of function of FBXW7 results in the stabilization of numerous proteins that orchestrate cell proliferation and survival. Lit...
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| Veröffentlicht in: | EMBO J |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5286380/ https://ncbi.nlm.nih.gov/pubmed/28007894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694795 |
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