The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCF (FBXW7) function

The F‐box protein FBXW7 is the substrate‐recruiting subunit of an SCF ubiquitin ligase and a major tumor‐suppressor protein that is altered in several human malignancies. Loss of function of FBXW7 results in the stabilization of numerous proteins that orchestrate cell proliferation and survival. Lit...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Reiterer, Veronika, Figueras‐Puig, Cristina, Le Guerroue, Francois, Confalonieri, Stefano, Vecchi, Manuela, Jalapothu, Dasaradha, Kanse, Sandip M, Deshaies, Raymond J, Di Fiore, Pier Paolo, Behrends, Christian, Farhan, Hesso
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286380/
https://ncbi.nlm.nih.gov/pubmed/28007894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694795
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