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HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma

Loss of primary cilia is frequently observed in tumor cells, including pancreatic ductal adenocarcinoma (PDAC) cells, suggesting that the absence of this organelle may promote tumorigenesis through aberrant signal transduction and the inability to exit the cell cycle. However, the molecular mechanis...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Kobayashi, Tetsuo, Nakazono, Kosuke, Tokuda, Mio, Mashima, Yu, Dynlacht, Brian David, Itoh, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286357/
https://ncbi.nlm.nih.gov/pubmed/28028031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541922
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