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HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma

Loss of primary cilia is frequently observed in tumor cells, including pancreatic ductal adenocarcinoma (PDAC) cells, suggesting that the absence of this organelle may promote tumorigenesis through aberrant signal transduction and the inability to exit the cell cycle. However, the molecular mechanis...

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Dettagli Bibliografici
Pubblicato in:EMBO Rep
Autori principali: Kobayashi, Tetsuo, Nakazono, Kosuke, Tokuda, Mio, Mashima, Yu, Dynlacht, Brian David, Itoh, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286357/
https://ncbi.nlm.nih.gov/pubmed/28028031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541922
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