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Transient cerebellar alterations during development prior to obvious motor phenotype in a mouse model of spinocerebellar ataxia type 6

KEY POINTS: Spinocerebellar ataxia type 6 (SCA6) is a midlife‐onset neurodegenerative disease caused by a CACNA1A mutation; CACNA1A is also implicated in cerebellar development. We have previously shown that when disease symptoms are present in midlife in SCA6(84Q/84Q) mice, cerebellar Purkinje cell...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Jayabal, Sriram, Ljungberg, Lovisa, Watt, Alanna J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5285638/
https://ncbi.nlm.nih.gov/pubmed/27531396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273184
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