A carregar...

4-aminopyridine reverses ataxia and cerebellar firing deficiency in a mouse model of spinocerebellar ataxia type 6

Spinocerebellar ataxia type 6 (SCA6) is a devastating midlife-onset autosomal dominant motor control disease with no known treatment. Using a hyper-expanded polyglutamine (84Q) knock-in mouse, we found that cerebellar Purkinje cell firing precision was degraded in heterozygous (SCA6(84Q/+)) mice at...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jayabal, Sriram, Chang, Hui Ho Vanessa, Cullen, Kathleen E., Watt, Alanna J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933933/
https://ncbi.nlm.nih.gov/pubmed/27381005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29489
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!