ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

Genes encoding subunits of SWI/SNF chromatin remodeling complexes are collectively mutated in ~20% of all human cancers(1–2). Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis is unclear. Here, we demonstrate that Arid1a function...

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Pubblicato in:Nat Genet
Autori principali: Mathur, Radhika, Alver, Burak Han, San Roman, Adrianna K., Wilson, Boris G., Wang, Xiaofeng, Agoston, Agoston T., Park, Peter J., Shivdasani, Ramesh A., Roberts, Charles W. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5285448/
https://ncbi.nlm.nih.gov/pubmed/27941798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3744
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