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Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth
SMARCB1 (INI1/SNF5/BAF47), a core subunit of the SWI/SNF (BAF) chromatin-remodeling complex, is inactivated in the large majority of rhabdoid tumors and germline heterozygous SMARCB1 mutations form the basis for rhabdoid predisposition syndrome. Mouse models validated Smarcb1 as a bona fide tumor su...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4195815/ https://ncbi.nlm.nih.gov/pubmed/24853101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergen.2014.04.004 |
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