p53 is a master regulator of proteostasis in SMARCB1-deficient malignant rhabdoid tumors

Alterations in chromatin remodeling genes have been increasingly implicated in human oncogenesis. Specifically, the biallelic inactivation of the SWI/SNF subunit SMARCB1 results in the emergence of extremely aggressive pediatric malignancies. Here, we developed embryonic mosaic mouse models of malig...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Carugo, Alessandro, Minelli, Rosalba, Sapio, Luigi, Soeung, Melinda, Carbone, Federica, Robinson, Frederick S., Tepper, James, Ziheng, Chen, Lovisa, Sara, Svelto, Maria, Amin, Samirkumar, Srinivasan, Sanjana, Del Poggetto, Edoardo, Loponte, Sara, Puca, Francesca, Dey, Prasenjit, Malouf, Gabriel G., Su, Xiaoping, Li, Liren, Lopez-Terrada, Dolores, Rakheja, Dinesh, Lazar, Alexander J., Netto, George J., Rao, Priya, Sgambato, Alessandro, Maitra, Anirban, Tripathi, Durga N., Walker, Cheryl L., Karam, Jose A., Heffernan, Timothy P., Viale, Andrea, Roberts, Charles W. M., Msaouel, Pavlos, Tannir, Nizar M., Draetta, Giulio F., Genovese, Giannicola
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876656/
https://ncbi.nlm.nih.gov/pubmed/30753823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.01.006
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