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ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
Genes encoding subunits of SWI/SNF chromatin remodeling complexes are collectively mutated in ~20% of all human cancers(1–2). Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis is unclear. Here, we demonstrate that Arid1a function...
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| Publicat a: | Nat Genet |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5285448/ https://ncbi.nlm.nih.gov/pubmed/27941798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3744 |
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