Conversion of the E1A Cys4 zinc finger to a nonfunctional His2,Cys2 zinc finger by a single point mutation.

Trans-activation by the adenovirus E1A 289R protein requires a zinc finger defined by Cys-154, Cys-157, Cys-171, and Cys-174. Whereas individually replacing the four cysteine residues with serines resulted in a loss of transactivation, only three of the Cys----Ser mutants (C157S, C171S, and C174S) l...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Webster, L C, Zhang, K, Chance, B, Ayene, I, Culp, J S, Huang, W J, Wu, F Y, Ricciardi, R P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52852/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1835093/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.22.9989
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