Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release

OBJECTIVE: Caffeine reduces toxic Ca(2+) signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP(3)R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP). We have determin...

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Foilsithe in:Gut
Main Authors: Huang, Wei, Cane, Matthew C, Mukherjee, Rajarshi, Szatmary, Peter, Zhang, Xiaoying, Elliott, Victoria, Ouyang, Yulin, Chvanov, Michael, Latawiec, Diane, Wen, Li, Booth, David M, Haynes, Andrea C, Petersen, Ole H, Tepikin, Alexei V, Criddle, David N, Sutton, Robert
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMJ Publishing Group 2017
Ábhair:
Pancreas
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5284483/
https://ncbi.nlm.nih.gov/pubmed/26642860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-309363
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