Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release

OBJECTIVE: Caffeine reduces toxic Ca(2+) signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP(3)R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP). We have determin...

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Bibliographic Details
Published in:Gut
Main Authors: Huang, Wei, Cane, Matthew C, Mukherjee, Rajarshi, Szatmary, Peter, Zhang, Xiaoying, Elliott, Victoria, Ouyang, Yulin, Chvanov, Michael, Latawiec, Diane, Wen, Li, Booth, David M, Haynes, Andrea C, Petersen, Ole H, Tepikin, Alexei V, Criddle, David N, Sutton, Robert
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2017
Subjects:
Pancreas
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5284483/
https://ncbi.nlm.nih.gov/pubmed/26642860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-309363
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