Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release

OBJECTIVE: Caffeine reduces toxic Ca(2+) signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP(3)R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP). We have determin...

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Опубликовано в: :Gut
Главные авторы: Huang, Wei, Cane, Matthew C, Mukherjee, Rajarshi, Szatmary, Peter, Zhang, Xiaoying, Elliott, Victoria, Ouyang, Yulin, Chvanov, Michael, Latawiec, Diane, Wen, Li, Booth, David M, Haynes, Andrea C, Petersen, Ole H, Tepikin, Alexei V, Criddle, David N, Sutton, Robert
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2017
Предметы:
Pancreas
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5284483/
https://ncbi.nlm.nih.gov/pubmed/26642860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-309363
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