Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release

OBJECTIVE: Caffeine reduces toxic Ca(2+) signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP(3)R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP). We have determin...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Gut
Egile Nagusiak: Huang, Wei, Cane, Matthew C, Mukherjee, Rajarshi, Szatmary, Peter, Zhang, Xiaoying, Elliott, Victoria, Ouyang, Yulin, Chvanov, Michael, Latawiec, Diane, Wen, Li, Booth, David M, Haynes, Andrea C, Petersen, Ole H, Tepikin, Alexei V, Criddle, David N, Sutton, Robert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMJ Publishing Group 2017
Gaiak:
Pancreas
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5284483/
https://ncbi.nlm.nih.gov/pubmed/26642860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-309363
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