Maturity and age influence chief cell ability to transdifferentiate into metaplasia

The plasticity of gastric chief cells is exemplified by their ability to transdifferentiate into spasmolytic polypeptide-expressing metaplasia (SPEM) after parietal cell loss. We sought to determine if chief cell maturity is a limiting factor in the capacity to transdifferentiate. Mist1(−)(/−) mice,...

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Udgivet i:Am J Physiol Gastrointest Liver Physiol
Main Authors: Weis, Victoria G., Petersen, Christine P., Weis, Jared A., Meyer, Anne R., Choi, Eunyoung, Mills, Jason C., Goldenring, James R.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283902/
https://ncbi.nlm.nih.gov/pubmed/27881402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00326.2016
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