HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains

The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is crucial for the development of adult T-cell leukemia (ATL), a highly malignant CD4(+) T cell neoplasm. Among the multiple aberrant Tax-induced effects on cellular processes, persistent activation of transcription factor NF-κB, which i...

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Foilsithe in:PLoS Pathog
Main Authors: Shibata, Yuri, Tokunaga, Fuminori, Goto, Eiji, Komatsu, Ginga, Gohda, Jin, Saeki, Yasushi, Tanaka, Keiji, Takahashi, Hirotaka, Sawasaki, Tatsuya, Inoue, Satoshi, Oshiumi, Hiroyuki, Seya, Tsukasa, Nakano, Hiroyasu, Tanaka, Yuetsu, Iwai, Kazuhiro, Inoue, Jun-ichiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283754/
https://ncbi.nlm.nih.gov/pubmed/28103322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006162
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