MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition

Advanced lung cancer has poor survival with few therapies. EGFR tyrosine kinase inhibitors (TKIs) have high response rates in patients with activating EGFR mutations, but acquired resistance is inevitable. Acquisition of the EGFR T790M mutation causes over 50% of resistance; MET amplification is als...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ortiz-Zapater, Elena, Lee, Richard W., Owen, William, Weitsman, Gregory, Fruhwirth, Gilbert, Dunn, Robert G., Neat, Michael J., McCaughan, Frank, Parker, Peter, Ng, Tony, Santis, George
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283661/
https://ncbi.nlm.nih.gov/pubmed/28141869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170798
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