QSAR-Driven Discovery of Novel Chemical Scaffolds Active Against Schistosoma mansoni

Schistosomiasis is a neglected tropical disease that affects millions of people worldwide. Thioredoxin glutathione reductase of Schistosoma mansoni (SmTGR) is a validated drug target that plays a crucial role in the redox homeostasis of the parasite. We report the discovery of new chemical scaffolds...

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Vydáno v:J Chem Inf Model
Hlavní autoři: Melo-Filho, Cleber C., Dantas, Rafael F., Braga, Rodolpho C., Neves, Bruno J., Senger, Mario R., Valente, Walter C.G., Rezende-Neto, João M., Chaves, Willian T., Muratov, Eugene N., Paveley, Ross A., Furnham, Nicholas, Kamentsky, Lee, Carpenter, Anne E., Silva-Junior, Floriano P., Andrade, Carolina H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283162/
https://ncbi.nlm.nih.gov/pubmed/27253773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.6b00055
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