The Pattern of Retinal Ganglion Cell Loss in OPA1-Related Autosomal Dominant Optic Atrophy Inferred From Temporal, Spatial, and Chromatic Sensitivity Losses

PURPOSE: Progressive retinal ganglion cell (RGC) loss is the pathological hallmark of autosomal dominant optic atrophy (DOA) caused by pathogenic OPA1 mutations. The aim of this study was to conduct an in-depth psychophysical study of the visual losses in DOA and to infer any selective vulnerability...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Majander, Anna, João, Catarina, Rider, Andrew T., Henning, G. Bruce, Votruba, Marcela, Moore, Anthony T., Yu-Wai-Man, Patrick, Stockman, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2017
Témata:
Visual Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283089/
https://ncbi.nlm.nih.gov/pubmed/28125838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20309
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