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Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300

Nonsteroidal anti-inflammatory drugs are the most widely used medicine to treat pain and inflammation, and to inhibit platelet function. Understanding the expression regulation of enzymes of the prostanoid pathway is of great medical relevance. Histone acetylation crucially controls gene expression....

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Détails bibliographiques
Publié dans:J Lipid Res
Auteurs principaux: Fork, Christian, Vasconez, Andrea E., Janetzko, Patrick, Angioni, Carlo, Schreiber, Yannick, Ferreirós, Nerea, Geisslinger, Gerd, Leisegang, Matthias S., Steinhilber, Dieter, Brandes, Ralf P.
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282954/
https://ncbi.nlm.nih.gov/pubmed/27913583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M072280
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