S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization

HDL normally transports about 50–70% of plasma sphingosine 1-phosphate (S1P), and the S1P in HDL reportedly mediates several HDL-associated biological effects and signaling pathways. The HDL receptor, SR-BI, as well as the cell surface receptors for S1P (S1PRs) may be involved partially and/or compl...

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Опубликовано в: :J Lipid Res
Главные авторы: Lee, Mi-Hye, Appleton, Kathryn M., El-Shewy, Hesham M., Sorci-Thomas, Mary G., Thomas, Michael J., Lopes-Virella, Maria F., Luttrell, Louis M., Hammad, Samar M., Klein, Richard L.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2017
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282949/
https://ncbi.nlm.nih.gov/pubmed/27881715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M070706
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