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The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity

Many side effects of current FDA-approved L-asparaginases have been related to their secondary L-glutaminase activity. The Wolinella succinogenes L-asparaginase (WoA) has been reported to be L-glutaminase free, suggesting it would have fewer side effects. Unexpectedly, the WoA variant with a proline...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Nguyen, Hien Anh, Durden, Donald L., Lavie, Arnon
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282591/
https://ncbi.nlm.nih.gov/pubmed/28139703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41643
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