The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores

The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes. In these pathways Sgt1 interacts with Skp1, a small protein that heterodimerizes with proteins containing the F-box motif. We have det...

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Vydáno v:Sci Rep
Hlavní autoři: Willhoft, Oliver, Kerr, Richard, Patel, Dipali, Zhang, Wenjuan, Al-Jassar, Caezar, Daviter, Tina, Millson, Stefan H., Thalassinos, Konstantinos, Vaughan, Cara K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282575/
https://ncbi.nlm.nih.gov/pubmed/28139700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41626
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