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The mechanism of formation, structure and physiological relevance of covalent hemoglobin attachment to the erythrocyte membrane

Covalent hemoglobin binding to membranes leads to band 3 (AE1) clustering and the removal of erythrocytes from the circulation; it is also implicated in blood storage lesions. Damaged hemoglobin, with the heme being in a redox and oxygen-binding inactive hemichrome form, has been implicated as the b...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Welbourn, Elizabeth M., Wilson, Michael T., Yusof, Ashril, Metodiev, Metodi V., Cooper, Chris E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282401/
https://ncbi.nlm.nih.gov/pubmed/28007575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.12.024
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