RNA Interference of Human α-Synuclein in Mouse

α-Synuclein is postulated to play a key role in the pathogenesis of Parkinson’s disease (PD). Aggregates of α-synuclein contribute to neurodegeneration and cell death in humans and in mouse models of PD. Here, we use virally mediated RNA interference to knockdown human α-synuclein in mice. We used a...

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Detalles Bibliográficos
Publicado en:Front Neurol
Autores principales: Kim, Young-Cho, Miller, Adam, Lins, Livia C. R. F., Han, Sang-Woo, Keiser, Megan S., Boudreau, Ryan L., Davidson, Beverly L., Narayanan, Nandakumar S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5281542/
https://ncbi.nlm.nih.gov/pubmed/28197125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2017.00013
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