Matrix Metalloproteinase-7 Is a Urinary Biomarker and Pathogenic Mediator of Kidney Fibrosis

Matrix metalloproteinase-7 (MMP-7), a secreted zinc– and calcium–dependent endopeptidase, is a transcriptional target of canonical Wnt/β-catenin signaling. Because Wnt/β-catenin is activated in diseased kidney, we hypothesized that urinary MMP-7 level may be used as a noninvasive surrogate biomarker...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Zhou, Dong, Tian, Yuan, Sun, Ling, Zhou, Lili, Xiao, Liangxiang, Tan, Roderick J., Tian, Jianwei, Fu, Haiyan, Hou, Fan Fan, Liu, Youhua
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2017
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5280025/
https://ncbi.nlm.nih.gov/pubmed/27624489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016030354
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