A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection

The intestinal epithelium can limit enteric pathogens by producing antiviral cytokines, such as IFNs. Type I IFN (IFN-α/β) and type III IFN (IFN-λ) function at the epithelial level, and their respective efficacies depend on the specific pathogen and site of infection. However, the roles of type I an...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Saxena, Kapil, Simon, Lukas M., Zeng, Xi-Lei, Blutt, Sarah E., Crawford, Sue E., Sastri, Narayan P., Karandikar, Umesh C., Ajami, Nadim J., Zachos, Nicholas C., Kovbasnjuk, Olga, Donowitz, Mark, Conner, Margaret E., Shaw, Chad A., Estes, Mary K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278484/
https://ncbi.nlm.nih.gov/pubmed/28069942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615422114
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