Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site

Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific mono...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Xiangxi, Zhu, Ling, Dang, Minghao, Hu, Zhongyu, Gao, Qiang, Yuan, Shuai, Sun, Yao, Zhang, Bo, Ren, Jingshan, Kotecha, Abhay, Walter, Thomas S., Wang, Junzhi, Fry, Elizabeth E., Stuart, David I., Rao, Zihe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278457/
https://ncbi.nlm.nih.gov/pubmed/28074040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616502114
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