REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6

The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21...

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Bibliografiske detaljer
Udgivet i:Biol Open
Main Authors: Chavan, Rohit, Preitner, Nadia, Okabe, Takashi, Strittmatter, Laureen Mansencal, Xu, Cheng, Ripperger, Jürgen A., Pitteloud, Nelly, Albrecht, Urs
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278426/
https://ncbi.nlm.nih.gov/pubmed/27875243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.021519
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