Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene.

We have generated transgenic mice harboring a glycine-to-cysteine mutation in residue 85 of the triple helical domain of mouse type II collagen. The offspring of different founders displayed a phenotype of severe chondrodysplasia characterized by short limbs and trunk, cranio-facial deformities, and...

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Detalhes bibliográficos
Main Authors: Garofalo, S, Vuorio, E, Metsaranta, M, Rosati, R, Toman, D, Vaughan, J, Lozano, G, Mayne, R, Ellard, J, Horton, W
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC52775/
https://ncbi.nlm.nih.gov/pubmed/1946380
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