Mercury(II) binds to both of chymotrypsin's histidines, causing inhibition followed by irreversible denaturation/aggregation

The toxicity of mercury is often attributed to its tight binding to cysteine thiolate anions in vital enzymes. To test our hypothesis that Hg(II) binding to histidine could be a significant factor in mercury's toxic effects, we studied the enzyme chymotrypsin, which lacks free cysteine thiols;...

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Detaylı Bibliyografya
Yayımlandı:Protein Sci
Asıl Yazarlar: Stratton, Amanda, Ericksen, Matthew, Harris, Travis V., Symmonds, Nick, Silverstein, Todd P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5275735/
https://ncbi.nlm.nih.gov/pubmed/27859834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3082
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