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Spatial control of irreversible protein aggregation

Liquid cellular compartments form in the cyto- or nucleoplasm and can regulate aberrant protein aggregation. Yet, the mechanisms by which these compartments affect protein aggregation remain unknown. Here, we combine kinetic theory of protein aggregation and liquid-liquid phase separation to study t...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Weber, Christoph, Michaels, Thomas, Mahadevan, L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516824/
https://ncbi.nlm.nih.gov/pubmed/31084715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42315
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